Structural and functional analysis reveals that human OASL binds dsRNA to enhance RIG-I signaling

The oligoadenylate synthetase (OAS) enzymes are cytoplasmic dsRNA sensors belonging to the antiviral innate immune system. Upon binding to viral dsRNA, the OAS enzymes synthesize 2′-5′ linked oligoadenylates (2-5As) that initiate an RNA decay pathway to impair viral replication. The human OAS-like (...

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Detalles Bibliográficos
Publicado en:Nucleic Acids Res
Autores principales: Ibsen, Mikkel Søes, Gad, Hans Henrik, Andersen, Line Lykke, Hornung, Veit, Julkunen, Ilkka, Sarkar, Saumendra N., Hartmann, Rune
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2015
Materias:
Structural Biology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4446440/
https://ncbi.nlm.nih.gov/pubmed/25925578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv389
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