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RAR/RXR binding dynamics distinguish pluripotency from differentiation associated cis-regulatory elements
In mouse embryonic cells, ligand-activated retinoic acid receptors (RARs) play a key role in inhibiting pluripotency-maintaining genes and activating some major actors of cell differentiation. To investigate the mechanism underlying this dual regulation, we performed joint RAR/RXR ChIP-seq and mRNA-...
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| Publié dans: | Nucleic Acids Res |
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| Auteurs principaux: | , , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Oxford University Press
2015
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4446430/ https://ncbi.nlm.nih.gov/pubmed/25897113 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv370 |
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