RAR/RXR binding dynamics distinguish pluripotency from differentiation associated cis-regulatory elements

In mouse embryonic cells, ligand-activated retinoic acid receptors (RARs) play a key role in inhibiting pluripotency-maintaining genes and activating some major actors of cell differentiation. To investigate the mechanism underlying this dual regulation, we performed joint RAR/RXR ChIP-seq and mRNA-...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Nucleic Acids Res
Päätekijät: Chatagnon, Amandine, Veber, Philippe, Morin, Valérie, Bedo, Justin, Triqueneaux, Gérard, Sémon, Marie, Laudet, Vincent, d'Alché-Buc, Florence, Benoit, Gérard
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Oxford University Press 2015
Aiheet:
Gene regulation, Chromatin and Epigenetics
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4446430/
https://ncbi.nlm.nih.gov/pubmed/25897113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv370
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