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Mitochondrial Dysfunction in Human Leukemic Stem/Progenitor Cells upon Loss of RAC2

Leukemic stem cells (LSCs) reside within bone marrow niches that maintain their relatively quiescent state and convey resistance to conventional treatment. Many of the microenvironmental signals converge on RAC GTPases. Although it has become clear that RAC proteins fulfill important roles in the he...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Capala, Marta E., Maat, Henny, Bonardi, Francesco, van den Boom, Vincent, Kuipers, Jeroen, Vellenga, Edo, Giepmans, Ben N. G., Schuringa, Jan Jacob
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4446344/
https://ncbi.nlm.nih.gov/pubmed/26016997
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0128585
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