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Death of Neurons following Injury Requires Conductive Neuronal Gap Junction Channels but Not a Specific Connexin

Pharmacological blockade or genetic knockout of neuronal connexin 36 (Cx36)-containing gap junctions reduces neuronal death caused by ischemia, traumatic brain injury and NMDA receptor (NMDAR)-mediated excitotoxicity. However, whether Cx36 gap junctions contribute to neuronal death via channel-depen...

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Библиографические подробности
Опубликовано в: :PLoS One
Главные авторы: Fontes, Joseph D., Ramsey, Jon, Polk, Jeremy M, Koop, Andre, Denisova, Janna V., Belousov, Andrei B.
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2015
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4446213/
https://ncbi.nlm.nih.gov/pubmed/26017008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0125395
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