A Phase I Trial of DFMO Targeting Polyamine Addiction in Patients with Relapsed/Refractory Neuroblastoma

BACKGROUND: Neuroblastoma (NB) is the most common cancer in infancy and most frequent cause of death from extracranial solid tumors in children. Ornithine decarboxylase (ODC) expression is an independent indicator of poor prognosis in NB patients. This study investigated safety, response, pharmacoki...

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Veröffentlicht in:PLoS One
Hauptverfasser: Saulnier Sholler, Giselle L., Gerner, Eugene W., Bergendahl, Genevieve, MacArthur, Robert B., VanderWerff, Alyssa, Ashikaga, Takamaru, Bond, Jeffrey P., Ferguson, William, Roberts, William, Wada, Randal K., Eslin, Don, Kraveka, Jacqueline M., Kaplan, Joel, Mitchell, Deanna, Parikh, Nehal S., Neville, Kathleen, Sender, Leonard, Higgins, Timothy, Kawakita, Masao, Hiramatsu, Kyoko, Moriya, Shun-suke, Bachmann, André S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2015
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4446210/
https://ncbi.nlm.nih.gov/pubmed/26018967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0127246
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