A Phase I Trial of DFMO Targeting Polyamine Addiction in Patients with Relapsed/Refractory Neuroblastoma

BACKGROUND: Neuroblastoma (NB) is the most common cancer in infancy and most frequent cause of death from extracranial solid tumors in children. Ornithine decarboxylase (ODC) expression is an independent indicator of poor prognosis in NB patients. This study investigated safety, response, pharmacoki...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Saulnier Sholler, Giselle L., Gerner, Eugene W., Bergendahl, Genevieve, MacArthur, Robert B., VanderWerff, Alyssa, Ashikaga, Takamaru, Bond, Jeffrey P., Ferguson, William, Roberts, William, Wada, Randal K., Eslin, Don, Kraveka, Jacqueline M., Kaplan, Joel, Mitchell, Deanna, Parikh, Nehal S., Neville, Kathleen, Sender, Leonard, Higgins, Timothy, Kawakita, Masao, Hiramatsu, Kyoko, Moriya, Shun-suke, Bachmann, André S.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4446210/
https://ncbi.nlm.nih.gov/pubmed/26018967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0127246
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