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Protein synthesis elongation factor EF-1 alpha is essential for ubiquitin-dependent degradation of certain N alpha-acetylated proteins and may be substituted for by the bacterial elongation factor EF-Tu.

Targeting of different cellular proteins for conjugation and subsequent degradation via the ubiquitin pathway involves diverse recognition signals and distinct enzymatic factors. A few proteins are recognized via their N-terminal amino acid residue and conjugated by a ubiquitin-protein ligase that r...

Celý popis

Uloženo v:
Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Gonen, H, Smith, C E, Siegel, N R, Kahana, C, Merrick, W C, Chakraburtty, K, Schwartz, A L, Ciechanover, A
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 1994
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC44459/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8052636/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.16.7648
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