Regulation of Aspartyl-(Asparaginyl)-β-Hydroxylase Protein Expression and Function by Phosphorylation in Hepatocellular Carcinoma Cells

BACKGROUND: Asparaginyl-β-hydroxylase (AAH) promotes cell adhesion, migration, and invasion via Notch activation. AAH’s expression is up-regulated by insulin/IGF signaling through PI3K-Akt, but its protein is independently regulated by GSK-3β. The multiple predicted GSK-3β phosphorylation sites sugg...

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Publicado no:J Nat Sci
Main Authors: Borgas, Diana L., Gao, Jin-Song, Tong, Ming, Roper, Nitin, de la Monte, Suzanne M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4445734/
https://ncbi.nlm.nih.gov/pubmed/26029741
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