Cyclooxygenase-2 Silencing for the Treatment of Colitis: A Combined In Vivo Strategy Based on RNA Interference and Engineered Escherichia Coli

Nonpathogenic-invasive Escherichia coli (InvColi) bacteria are suitable for genetic transfer into mammalian cells and may act as a vehicle for RNA Interference (RNAi) in vivo. Cyclooxygenase-2 (COX-2) is overexpressed in ulcerative colitis (UC) and Crohn's disease (CD), two inflammatory conditi...

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Veröffentlicht in:Mol Ther
Hauptverfasser: Spisni, Enzo, Valerii, Maria C, De Fazio, Luigia, Cavazza, Elena, Borsetti, Francesca, Sgromo, Annamaria, Candela, Marco, Centanni, Manuela, Rizello, Fernando, Strillacci, Antonio
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2015
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4445621/
https://ncbi.nlm.nih.gov/pubmed/25393372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2014.222
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