Selective cyclooxygenase-2 silencing mediated by engineered E. coli and RNA interference induces anti-tumour effects in human colon cancer cells

BACKGROUND: Cyclooxygenase-2 (COX-2) overexpression is strongly associated with colorectal tumourigenesis. It has been demonstrated that the chronic use of non-steroidal anti-inflammatory drugs (COX inhibitors) partially protects patients from colorectal cancer (CRC) development and progression but...

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Detalhes bibliográficos
Main Authors: Strillacci, A, Griffoni, C, Lazzarini, G, Valerii, M C, Di Molfetta, S, Rizzello, F, Campieri, M, Moyer, M P, Tomasi, V, Spisni, E
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2010
Assuntos:
Translational Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2965869/
https://ncbi.nlm.nih.gov/pubmed/20717114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6605859
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