Expression of O(6)-methylguanine-DNA methyltransferase causes lomustine resistance in canine lymphoma cells

The DNA repair protein O(6)-methylguanine-DNA methyltransferase (MGMT) causes resistance to nitrosoureas in various human cancers. In this study, we analyzed the correlation between canine lymphomas and MGMT in vitro. Two of five canine lymphoma cell lines required higher concentrations of lomustine...

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Veröffentlicht in:Can J Vet Res
Hauptverfasser: Kambayashi, Satoshi, Minami, Kouji, Ogawa, Yuka, Hamaji, Takehiro, Hwang, Chung Chew, Igase, Masaya, Hiraoka, Hiroko, Miyama, Takako Shimokawa, Noguchi, Shunsuke, Baba, Kenji, Mizuno, Takuya, Okuda, Masaru
Format: Artigo
Sprache:Inglês
Veröffentlicht: Canadian Veterinary Medical Association 2015
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4445512/
https://ncbi.nlm.nih.gov/pubmed/26130852
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