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Maintenance of Protein Synthesis Reading Frame by EF-P and m(1)G37-tRNA
Maintaining the translational reading frame poses difficulty for the ribosome. Slippery mRNA sequences such as CC[C/U]-[C/U], read by isoacceptors of tRNA(Pro), are highly prone to +1 frameshift (+1FS) errors. Here we show that +1FS errors occur by two mechanisms, a slow mechanism when tRNA(Pro) is...
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| Publicado no: | Nat Commun |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4445466/ https://ncbi.nlm.nih.gov/pubmed/26009254 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms8226 |
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