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Azasugar inhibitors as pharmacological chaperones for Krabbe disease
Krabbe disease is a devastating neurodegenerative disorder characterized by rapid demyelination of nerve fibers. This disease is caused by defects in the lysosomal enzyme β-galactocerebrosidase (GALC), which hydrolyzes the terminal galactose from glycosphingolipids. These lipids are essential compon...
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| 出版年: | Chem Sci |
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| 主要な著者: | , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Royal Society of Chemistry
2015
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4445328/ https://ncbi.nlm.nih.gov/pubmed/26029356 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c5sc00754b |
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