Amyloid Precursor Protein (APP) Affects Global Protein Synthesis in Dividing Human Cells

Hypoxic non‐small cell lung cancer (NSCLC) is dependent on Notch‐1 signaling for survival. Targeting Notch‐1 by means of γ‐secretase inhibitors (GSI) proved effective in killing hypoxic NSCLC. Post‐mortem analysis of GSI‐treated, NSCLC‐burdened mice suggested enhanced phosphorylation of 4E‐BP1 at th...

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Bibliografiske detaljer
Udgivet i:J Cell Physiol
Main Authors: Sobol, Anna, Galluzzo, Paola, Liang, Shuang, Rambo, Brittany, Skucha, Sylvia, Weber, Megan J., Alani, Sara, Bocchetta, Maurizio
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2015
Fag:
Original Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4445069/
https://ncbi.nlm.nih.gov/pubmed/25283437
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcp.24835
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