Efficient gene delivery to photoreceptors using AAV2/rh10 and rescue of the Rho(–/–) mouse

As gene therapies for various forms of retinal degeneration progress toward human clinical trial, it will be essential to have a repertoire of safe and efficient vectors for gene delivery to the target cells. Recombinant adeno-associated virus (AAV) serotype 2/2 has been shown to be well tolerated i...

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Detalhes bibliográficos
Publicado no:Mol Ther Methods Clin Dev
Main Authors: Palfi, Arpad, Chadderton, Naomi, O’Reilly, Mary, Nagel-Wolfrum, Kerstin, Wolfrum, Uwe, Bennett, Jean, Humphries, Peter, Kenna, Paul, Millington-Ward, Sophia, Farrar, Jane
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4444994/
https://ncbi.nlm.nih.gov/pubmed/26029727
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtm.2015.16
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