AAV-PHP.eB transduces both the inner and outer retina with high efficacy in mice

Recombinant adeno-associated virus (AAV) vectors are one of the main gene delivery vehicles used in retinal gene therapy approaches; however, there is a need to further improve the efficacy, tropism, and safety of these vectors. In this study, using a CMV-EGFP expression cassette, we characterize th...

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Detalhes bibliográficos
Main Authors: Arpad Palfi, Naomi Chadderton, Sophia Millington-Ward, Iris Post, Pete Humphries, Paul F. Kenna, G. Jane Farrar
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2022-06-01
Colecção:Molecular Therapy: Methods & Clinical Development
Assuntos:
retina
eye
mouse
AAV2/2
AAV2/8
AAV-PHP.eB
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2329050122000468
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