Disabling Mitochondrial Peroxide Metabolism via Combinatorial Targeting of Peroxiredoxin 3 as an Effective Therapeutic Approach for Malignant Mesothelioma

Dysregulation of signaling pathways and energy metabolism in cancer cells enhances production of mitochondrial hydrogen peroxide that supports tumorigenesis through multiple mechanisms. To counteract the adverse effects of mitochondrial peroxide many solid tumor types up-regulate the mitochondrial t...

詳細記述

保存先:
書誌詳細
出版年:PLoS One
主要な著者: Cunniff, Brian, Newick, Kheng, Nelson, Kimberly J., Wozniak, Alexandra N., Beuschel, Stacie, Leavitt, Bruce, Bhave, Anant, Butnor, Kelly, Koenig, Andreas, Chouchani, Edward T., James, Andrew M., Haynes, Alexina C., Lowther, W. Todd, Murphy, Michael P., Shukla, Arti, Heintz, Nicholas H.
フォーマット: Artigo
言語:Inglês
出版事項: Public Library of Science 2015
主題:
Research Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4444329/
https://ncbi.nlm.nih.gov/pubmed/26011724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0127310
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