Disabling Mitochondrial Peroxide Metabolism via Combinatorial Targeting of Peroxiredoxin 3 as an Effective Therapeutic Approach for Malignant Mesothelioma

Dysregulation of signaling pathways and energy metabolism in cancer cells enhances production of mitochondrial hydrogen peroxide that supports tumorigenesis through multiple mechanisms. To counteract the adverse effects of mitochondrial peroxide many solid tumor types up-regulate the mitochondrial t...

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發表在:PLoS One
Main Authors: Cunniff, Brian, Newick, Kheng, Nelson, Kimberly J., Wozniak, Alexandra N., Beuschel, Stacie, Leavitt, Bruce, Bhave, Anant, Butnor, Kelly, Koenig, Andreas, Chouchani, Edward T., James, Andrew M., Haynes, Alexina C., Lowther, W. Todd, Murphy, Michael P., Shukla, Arti, Heintz, Nicholas H.
格式: Artigo
語言:Inglês
出版: Public Library of Science 2015
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4444329/
https://ncbi.nlm.nih.gov/pubmed/26011724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0127310
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