Discovery of Novel Isoforms of Huntingtin Reveals a New Hominid-Specific Exon

Huntington’s disease (HD) is a devastating neurological disorder that is caused by an expansion of the poly-Q tract in exon 1 of the Huntingtin gene (HTT). HTT is an evolutionarily conserved and ubiquitously expressed protein that has been linked to a variety of functions including transcriptional r...

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Détails bibliographiques
Publié dans:PLoS One
Auteurs principaux: Ruzo, Albert, Ismailoglu, Ismail, Popowski, Melissa, Haremaki, Tomomi, Croft, Gist F., Deglincerti, Alessia, Brivanlou, Ali H.
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2015
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4444280/
https://ncbi.nlm.nih.gov/pubmed/26010866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0127687
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