Hemoglobin βCys93 is essential for cardiovascular function and integrated response to hypoxia

Oxygen delivery by Hb is essential for vertebrate life. Three amino acids in Hb are strictly conserved in all mammals and birds, but only two of those, a His and a Phe that stabilize the heme moiety, are needed to carry O(2). The third conserved residue is a Cys within the β-chain (βCys93) that has...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Zhang, Rongli, Hess, Douglas T., Qian, Zhaoxia, Hausladen, Alfred, Fonseca, Fabio, Chaube, Ruchi, Reynolds, James D., Stamler, Jonathan S.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2015
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4443356/
https://ncbi.nlm.nih.gov/pubmed/25810253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1502285112
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