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Lack of pairing during meiosis triggers multigenerational transgene silencing in Caenorhabditis elegans
Single-copy transgenes in Caenorhabditis elegans can be subjected to a potent, irreversible silencing process termed small RNA-induced epigenetic silencing (RNAe). RNAe is promoted by the Piwi Argonaute protein PRG-1 and associated Piwi-interacting RNAs (piRNAs), as well as by proteins that promote...
Shranjeno v:
| izdano v: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
National Academy of Sciences
2015
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4443339/ https://ncbi.nlm.nih.gov/pubmed/25941370 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1501979112 |
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