Viral Induced CD28 Loss Evokes Costimulation Independent Alloimmunity

BACKGROUND: Belatacept, a B7-specific fusion protein, blocks CD28-B7 costimulation and prevents kidney allograft rejection. However, it is ineffective in a sizable minority of patients. Although T cell receptor and CD28 engagement is known to initiate T cell activation, many human antigen-experience...

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Bibliografiska uppgifter
I publikationen:J Surg Res
Huvudupphovsmän: Mou, Danny, Espinosa, Jaclyn E., Stempora, Linda, Iwakoshi, Neal N., Kirk, Allan D.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2015
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4442743/
https://ncbi.nlm.nih.gov/pubmed/25801976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jss.2015.02.033
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