Anti-V3/Glycan and Anti-MPER Neutralizing Antibodies, but Not Anti-V2/Glycan Site Antibodies, Are Strongly Associated with Greater Anti-HIV-1 Neutralization Breadth and Potency

The membrane-proximal external region (MPER), the V2/glycan site (initially defined by PG9 and PG16 antibodies), and the V3/glycans (initially defined by PGT121–128 antibodies) are targets of broadly neutralizing antibodies and potential targets for anti-HIV-1 antibody-based vaccines. Recent evidenc...

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Bibliographische Detailangaben
Veröffentlicht in:J Virol
Hauptverfasser: Jacob, Rajesh Abraham, Moyo, Thandeka, Schomaker, Michael, Abrahams, Fatima, Grau Pujol, Berta, Dorfman, Jeffrey R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2015
Schlagworte:
Vaccines and Antiviral Agents
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4442498/
https://ncbi.nlm.nih.gov/pubmed/25673728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00129-15
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