Simian Immunodeficiency Virus SIVsab Infection of Rhesus Macaques as a Model of Complete Immunological Suppression with Persistent Reservoirs of Replication-Competent Virus: Implications for Cure Research

Simian immunodeficiency virus SIVsab infection is completely controlled in rhesus macaques (RMs) through functional immune responses. We report that in SIVsab-infected RMs, (i) viral replication is controlled to <0 to 3 copies/ml, (ii) about one-third of the virus strains in reservoirs are replic...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Ma, Dongzhu, Xu, Cuiling, Cillo, Anthony R., Policicchio, Benjamin, Kristoff, Jan, Haret-Richter, George, Mellors, John W., Pandrea, Ivona, Apetrei, Cristian
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2015
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4442440/
https://ncbi.nlm.nih.gov/pubmed/25833043
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00256-15
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