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A Triple-Arginine Motif in the Amino-Terminal Domain and Oligomerization Are Required for HIV-1 Inhibition by Human MX2

We have employed molecular genetic approaches to understand the domain organization of the HIV-1 resistance factor myxovirus resistance 2 (MX2). First, we describe an essential triple-arginine motif in the amino-terminal domain. Second, we demonstrate that this 91-residue domain mediates antiviral a...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Goujon, Caroline, Greenbury, Rebecca A., Papaioannou, Stelios, Doyle, Tomas, Malim, Michael H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4442396/
https://ncbi.nlm.nih.gov/pubmed/25673704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00169-15
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