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Determinants of the activities of antifolates delivered into cells by folate-receptor-mediated endocytosis

PURPOSE: Elements in the endocytic process that are determinants of the activities of antifolates delivered by folate-receptor alpha (FRα) were explored. METHODS: Antifolate growth inhibition was assessed with a 1- or 5-day exposure in reduced folate carrier-null HeLa cell lines that express a high...

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Detalhes bibliográficos
Publicado no:Cancer Chemother Pharmacol
Principais autores: Zhao, Rongbao, Visentin, Michele, Goldman, I. David
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4442060/
https://ncbi.nlm.nih.gov/pubmed/25847479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-015-2733-8
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