The EGFR/ErbB3 Pathway Acts as a Compensatory Survival Mechanism upon c-Met Inhibition in Human c-Met(+) Hepatocellular Carcinoma

BACKGROUND: c-Met, a high-affinity receptor for Hepatocyte Growth Factor (HGF), plays a critical role in tumor growth, invasion, and metastasis. Hepatocellular carcinoma (HCC) patients with activated HGF/c-Met signaling have a significantly worse prognosis. Targeted therapies using c-Met tyrosine ki...

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Udgivet i:PLoS One
Main Authors: Steinway, Steven N., Dang, Hien, You, Hanning, Rountree, C. Bart, Ding, Wei
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4441360/
https://ncbi.nlm.nih.gov/pubmed/26000702
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0128159
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