Honokiol blocks and reverses cardiac hypertrophy in mice by activating mitochondrial SIRT3

Honokiol (HKL) is a natural biphenolic compound derived from the bark of magnolia trees with anti-inflammatory, anti-oxidative, anti-tumor and neuroprotective properties. Here we show that HKL blocks agonist-induced and pressure overload-mediated, cardiac hypertrophic responses, and ameliorates pre-...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Pillai, Vinodkumar B., Samant, Sadhana, Sundaresan, Nagalingam R., Raghuraman, Hariharasundaram, Kim, Gene, Bonner, Michael Y., Arbiser, Jack L., Walker, Douglas I., Jones, Dean P., Gius, David, Gupta, Mahesh P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4441304/
https://ncbi.nlm.nih.gov/pubmed/25871545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms7656
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