MOZ regulates B-cell progenitors and, consequently, Moz haploinsufficiency dramatically retards MYC-induced lymphoma development

The histone acetyltransferase MOZ (MYST3, KAT6A) is the target of recurrent chromosomal translocations fusing the MOZ gene to CBP, p300, NCOA3, or TIF2 in particularly aggressive cases of acute myeloid leukemia. In this study, we report the role of wild-type MOZ in regulating B-cell progenitor proli...

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Foilsithe in:Blood
Main Authors: Sheikh, Bilal N., Lee, Stanley C. W., El-Saafin, Farrah, Vanyai, Hannah K., Hu, Yifang, Pang, Swee Heng Milon, Grabow, Stephanie, Strasser, Andreas, Nutt, Stephen L., Alexander, Warren S., Smyth, Gordon K., Voss, Anne K., Thomas, Tim
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society of Hematology 2015
Ábhair:
Lymphoid Neoplasia
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4440887/
https://ncbi.nlm.nih.gov/pubmed/25605372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-08-594655
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