MOZ regulates B-cell progenitors and, consequently, Moz haploinsufficiency dramatically retards MYC-induced lymphoma development

The histone acetyltransferase MOZ (MYST3, KAT6A) is the target of recurrent chromosomal translocations fusing the MOZ gene to CBP, p300, NCOA3, or TIF2 in particularly aggressive cases of acute myeloid leukemia. In this study, we report the role of wild-type MOZ in regulating B-cell progenitor proli...

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Détails bibliographiques
Publié dans:Blood
Auteurs principaux: Sheikh, Bilal N., Lee, Stanley C. W., El-Saafin, Farrah, Vanyai, Hannah K., Hu, Yifang, Pang, Swee Heng Milon, Grabow, Stephanie, Strasser, Andreas, Nutt, Stephen L., Alexander, Warren S., Smyth, Gordon K., Voss, Anne K., Thomas, Tim
Format: Artigo
Langue:Inglês
Publié: American Society of Hematology 2015
Sujets:
Lymphoid Neoplasia
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4440887/
https://ncbi.nlm.nih.gov/pubmed/25605372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-08-594655
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