MOZ regulates B-cell progenitors and, consequently, Moz haploinsufficiency dramatically retards MYC-induced lymphoma development

The histone acetyltransferase MOZ (MYST3, KAT6A) is the target of recurrent chromosomal translocations fusing the MOZ gene to CBP, p300, NCOA3, or TIF2 in particularly aggressive cases of acute myeloid leukemia. In this study, we report the role of wild-type MOZ in regulating B-cell progenitor proli...

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Bibliografische gegevens
Gepubliceerd in:Blood
Hoofdauteurs: Sheikh, Bilal N., Lee, Stanley C. W., El-Saafin, Farrah, Vanyai, Hannah K., Hu, Yifang, Pang, Swee Heng Milon, Grabow, Stephanie, Strasser, Andreas, Nutt, Stephen L., Alexander, Warren S., Smyth, Gordon K., Voss, Anne K., Thomas, Tim
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society of Hematology 2015
Onderwerpen:
Lymphoid Neoplasia
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4440887/
https://ncbi.nlm.nih.gov/pubmed/25605372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-08-594655
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