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Rapid parallel synthesis of bioactive folded cyclotides using a tea-bag approach

We report here for the first time the rapid parallel production of bioactive folded cyclotides by using Fmoc-based solid-phase peptide synthesis in combination with a tea-bag approach. Using this approach we efficiently synthesized 15 different analogs of the CXCR4 antagonist cyclotide MCo-CVX-5c. C...

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Bibliografski detalji
Izdano u:Chembiochem
Glavni autori: Aboye, Teshome, Kuang, Yuting, Neamati, Nouri, Camarero, Julio A.
Format: Artigo
Jezik:Inglês
Izdano: 2015
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4440831/
https://ncbi.nlm.nih.gov/pubmed/25663016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201402691
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