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Selective Inhibition of Deactivated Mitochondrial Complex I by Biguanides
Biguanides are widely used antihyperglycemic agents for diabetes mellitus and prediabetes treatment. Complex I is the rate limiting step of the mitochondrial electron transport chain (ETC), a major source of mitochondrial free radical production, and a known target of biguanides. Complex I has two r...
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| Pubblicato in: | Biochemistry |
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| Autori principali: | , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2015
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4440585/ https://ncbi.nlm.nih.gov/pubmed/25719498 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi501473h |
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