The Ligand Binding Region of the Sigma-1 Receptor: Studies Utilizing Photoaffinity Probes, Sphingosine and N-Alkylamines

The sigma-1 receptor is a 26 kDa endoplasmic reticulum resident membrane protein that has been shown to have chaperone activity in addition to its promiscuous binding to pharmacological agents. Ligand binding domain(s) of the sigma-1 receptor have been identified using the E. coli expressed and puri...

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Bibliographic Details
Published in:Curr Pharm Des
Main Authors: Ruoho, Arnold E., Chu, Uyen B., Ramachandran, Subramaniam, Fontanilla, Dominique, Mavlyutov, Timur, Hajipour, Abdol R.
Format: Artigo
Language:Inglês
Published: 2012
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4440231/
https://ncbi.nlm.nih.gov/pubmed/22288412
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