Sab (Sh3bp5) dependence of JNK mediated inhibition of mitochondrial respiration in palmitic acid induced hepatocyte lipotoxicity

BACKGROUND & AIMS: Sustained JNK activation by saturated fatty acids plays a role in lipotoxicity and the pathogenesis of NASH. We have reported that the interaction of JNK with mitochondrial Sab leads to inhibition of respiration, increased ROS, cell death and hepatotoxicity. We tested whether...

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Detaylı Bibliyografya
Yayımlandı:J Hepatol
Asıl Yazarlar: Win, Sanda, Than, Tin Aung, Le, Bao Han Allison, García-Ruiz, Carmen, Fernandez-Checa, Jose C, Kaplowitz, Neil
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2015
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4439305/
https://ncbi.nlm.nih.gov/pubmed/25666017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jhep.2015.01.032
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