A critical role for PKR complexes with TRBP in immunometabolic regulation and eIF2α phosphorylation in obesity

Aberrant stress and inflammatory responses are key factors in the pathogenesis of obesity and metabolic dysfunction, and the double-stranded RNA-dependent kinase (PKR) has been proposed to play an important role in integrating these pathways. Here, we report the formation of a complex between PKR an...

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Gepubliceerd in:Cell Rep
Hoofdauteurs: Nakamura, Takahisa, Kunz, Ryan C., Zhang, Cai, Kimura, Taishi, Yuan, Celvie L., Baccaro, Brenna, Namiki, Yuka, Gygi, Steven P., Hotamisligil, Gökhan S.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2015
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4439210/
https://ncbi.nlm.nih.gov/pubmed/25843719
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.03.021
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