Impact of the H275Y and I223V Mutations in the Neuraminidase of the 2009 Pandemic Influenza Virus In Vitro and Evaluating Experimental Reproducibility

The 2009 pandemic H1N1 (H1N1pdm09) influenza virus is naturally susceptible to neuraminidase (NA) inhibitors, but mutations in the NA protein can cause oseltamivir resistance. The H275Y and I223V amino acid substitutions in the NA of the H1N1pdm09 influenza strain have been separately observed in pa...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Paradis, Eric G., Pinilla, Lady Tatiana, Holder, Benjamin P., Abed, Yacine, Boivin, Guy, Beauchemin, Catherine A.A.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4439092/
https://ncbi.nlm.nih.gov/pubmed/25992792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0126115
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