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Interferon-α inhibits CD4 T cell responses to interleukin-7 and interleukin-2 and selectively interferes with Akt signaling

Persistent type I IFN production occurs during chronic viral infections, such as HIV disease. As type I IFNs have antiproliferative activity, it is possible that chronic exposure to these cytokines could adversely affect T cell homeostasis. We investigated the capacity of IFN-α to impair T cell prol...

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Detalhes bibliográficos
Publicado no:J Leukoc Biol
Main Authors: Nguyen, Thao P., Bazdar, Doug A., Mudd, Joseph C., Lederman, Michael M., Harding, Clifford V., Hardy, Gareth A., Sieg, Scott F.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Leukocyte Biology 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4438745/
https://ncbi.nlm.nih.gov/pubmed/25784743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.4A0714-345RR
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