SKF83959 Produces Antidepressant Effects in a Chronic Social Defeat Stress Model of Depression through BDNF-TrkB Pathway

BACKGROUND: SKF83959 stimulates the phospholipase Cβ/inositol phosphate 3 pathway, resulting in the activation of Ca(2+)/calmodulin-dependent kinase IIα, which affects the synthesis of brain-derived neurotrophic factor, a neurotrophic factor critical for the pathophysiology of depression. Previous r...

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Publicado en:Int J Neuropsychopharmacol
Autores principales: Jiang, Bo, Wang, Fang, Yang, Si, Fang, Peng, Deng, Zhi-Fang, Xiao, Jun-Li, Hu, Zhuang-Li, Chen, Jian-Guo
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2015
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4438541/
https://ncbi.nlm.nih.gov/pubmed/25522427
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ijnp/pyu096
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