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Amyloid β peptide-induced inhibition of endothelial nitric oxide production involves oxidative stress-mediated constitutive eNOS/HSP90 interaction and disruption of agonist-mediated Akt activation
BACKGROUND: Amyloid β (Aβ)-induced vascular dysfunction significantly contributes to the pathogenesis of Alzheimer’s disease (AD). Aβ is known to impair endothelial nitric oxide synthase (eNOS) activity, thus inhibiting endothelial nitric oxide production (NO). METHOD: In this study, we investigated...
Zapisane w:
Wydane w: | J Neuroinflammation |
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Główni autorzy: | , , , , , , , , , , |
Format: | Artigo |
Język: | Inglês |
Wydane: |
BioMed Central
2015
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Hasła przedmiotowe: | |
Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4438457/ https://ncbi.nlm.nih.gov/pubmed/25935150 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-015-0304-x |
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