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Genetic Analysis of Connective Tissue Growth Factor as an Effector of Transforming Growth Factor β Signaling and Cardiac Remodeling

The matricellular secreted protein connective tissue growth factor (CTGF) is upregulated in response to cardiac injury or with transforming growth factor β (TGF-β) stimulation, where it has been suggested to function as a fibrotic effector. Here we generated transgenic mice with inducible heart-spec...

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Detalhes bibliográficos
Publicado no:Mol Cell Biol
Main Authors: Accornero, Federica, van Berlo, Jop H., Correll, Robert N., Elrod, John W., Sargent, Michelle A., York, Allen, Rabinowitz, Joseph E., Leask, Andrew, Molkentin, Jeffery D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4438237/
https://ncbi.nlm.nih.gov/pubmed/25870108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00199-15
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