PSA-NCAM-Negative Neural Crest Cells Emerging during Neural Induction of Pluripotent Stem Cells Cause Mesodermal Tumors and Unwanted Grafts

Tumorigenic potential of human pluripotent stem cells (hPSCs) is an important issue in clinical applications. Despite many efforts, PSC-derived neural precursor cells (NPCs) have repeatedly induced tumors in animal models even though pluripotent cells were not detected. We found that polysialic acid...

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Detalhes bibliográficos
Publicado no:Stem Cell Reports
Main Authors: Lee, Dongjin R., Yoo, Jeong-Eun, Lee, Jae Souk, Park, Sanghyun, Lee, Junwon, Park, Chul-Yong, Ji, Eunhyun, Kim, Han-Soo, Hwang, Dong-Youn, Kim, Dae-Sung, Kim, Dong-Wook
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4437469/
https://ncbi.nlm.nih.gov/pubmed/25937368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2015.04.002
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