A candidate gene study reveals association between a variant of the Peroxisome Proliferator-Activated Receptor Gamma (PPAR-γ) gene and systemic sclerosis

INTRODUCTION: The multifunctional nuclear receptor peroxisome proliferator-activated receptor gamma (PPAR-γ) has potent anti-fibrotic effects, and its expression and activity are impaired in patients with systemic sclerosis (SSc). We investigated PPAR-γ gene (PPARG) single nucleotide polymorphisms (...

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Veröffentlicht in:Arthritis Res Ther
Hauptverfasser: Marangoni, Roberta Goncalves, Korman, Benjamin D, Allanore, Yannick, Dieude, Philippe, Armstrong, Loren L, Rzhetskaya, Margarita, Hinchcliff, Monique, Carns, Mary, Podlusky, Sofia, Shah, Sanjiv J, Ruiz, Barbara, Hachulla, Eric, Tiev, Kiet, Cracowski, Jean-Luc, Varga, John, Hayes, M Geoffrey
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2015
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4437446/
https://ncbi.nlm.nih.gov/pubmed/25986483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13075-015-0641-2
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