c-Abl mediated tyrosine phosphorylation of paxillin regulates LPS-induced endothelial dysfunction and lung injury

Paxillin is phosphorylated at multiple residues; however, the role of tyrosine phosphorylation of paxillin in endothelial barrier dysfunction and acute lung injury (ALI) remains unclear. We used siRNA and site-specific nonphosphorylable mutants of paxillin to abrogate the function of paxillin to det...

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Published in:Am J Physiol Lung Cell Mol Physiol
Main Authors: Fu, Panfeng, Usatyuk, Peter V., Lele, Abhishek, Harijith, Anantha, Gregorio, Carol C., Garcia, Joe G. N., Salgia, Ravi, Natarajan, Viswanathan
Format: Artigo
Language:Inglês
Published: American Physiological Society 2015
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4437005/
https://ncbi.nlm.nih.gov/pubmed/25795725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00306.2014
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