c-Abl mediated tyrosine phosphorylation of paxillin regulates LPS-induced endothelial dysfunction and lung injury

Paxillin is phosphorylated at multiple residues; however, the role of tyrosine phosphorylation of paxillin in endothelial barrier dysfunction and acute lung injury (ALI) remains unclear. We used siRNA and site-specific nonphosphorylable mutants of paxillin to abrogate the function of paxillin to det...

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Publicado en:Am J Physiol Lung Cell Mol Physiol
Autores principales: Fu, Panfeng, Usatyuk, Peter V., Lele, Abhishek, Harijith, Anantha, Gregorio, Carol C., Garcia, Joe G. N., Salgia, Ravi, Natarajan, Viswanathan
Formato: Artigo
Lenguaje:Inglês
Publicado: American Physiological Society 2015
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4437005/
https://ncbi.nlm.nih.gov/pubmed/25795725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00306.2014
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