Intraneuronal APP and extracellular Aβ independently cause dendritic spine pathology in transgenic mouse models of Alzheimer’s disease

Alzheimer’s disease (AD) is thought to be caused by accumulation of amyloid-β protein (Aβ), which is a cleavage product of amyloid precursor protein (APP). Transgenic mice overexpressing APP have been used to recapitulate amyloid-β pathology. Among them, APP23 and APPswe/PS1deltaE9 (deltaE9) mice ar...

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Bibliografische gegevens
Gepubliceerd in:Acta Neuropathol
Hoofdauteurs: Zou, Chengyu, Montagna, Elena, Shi, Yuan, Peters, Finn, Blazquez-Llorca, Lidia, Shi, Song, Filser, Severin, Dorostkar, Mario M., Herms, Jochen
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Springer Berlin Heidelberg 2015
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Original Paper
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4436699/
https://ncbi.nlm.nih.gov/pubmed/25862638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-015-1421-4
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