VITAMIN C FACILITATES DOPAMINE NEURON DIFFERENTIATION IN FETAL MIDBRAIN THROUGH TET1- AND JMJD3-DEPENDENT EPIGENETIC CONTROL MANNER

Intracellular Vitamin C (VC) is maintained at high levels in the developing brain by the activity of sodium-dependent VC transporter 2 (Svct2), suggesting specific VC functions in brain development. A role of VC as a cofactor for Fe(II)-2-oxoglutarate-dependent dioxygenases has recently been suggest...

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Pubblicato in:Stem Cells
Autori principali: He, Xi-Biao, Kim, Mirang, Kim, Seon-Young, Yi, Sang-Hoon, Rhee, Yong-Hee, Kim, Taeho, Lee, Eun-Hye, Park, Chang-Hwan, Dixit, Shilpy, Harrison, Fiona E., Lee, Sang-Hun
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4435601/
https://ncbi.nlm.nih.gov/pubmed/25535150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/stem.1932
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