MiR-148a- and miR-216a-regulated Oncolytic Adenoviruses Targeting Pancreatic Tumors Attenuate Tissue Damage Without Perturbation of miRNA Activity

Oncolytic virotherapy shows promise for pancreatic ductal adenocarcinoma (PDAC) treatment, but there is the need to minimize associated-toxicities. In the current work, we engineered artificial target sites recognized by miR-216a and/or miR-148a to provide pancreatic tumor-selectivity to replication...

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Bibliografische gegevens
Gepubliceerd in:Mol Ther
Hoofdauteurs: Bofill-De Ros, Xavier, Gironella, Meritxell, Fillat, Cristina
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group 2014
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Original Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4435498/
https://ncbi.nlm.nih.gov/pubmed/24895996
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2014.98
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