Characterisation of a Novel Fc Conjugate of Macrophage Colony-stimulating Factor

We have produced an Fc conjugate of colony-stimulating factor (CSF) 1 with an improved circulating half-life. CSF1-Fc retained its macrophage growth-promoting activity, and did not induce proinflammatory cytokines in vitro. Treatment with CSF1-Fc did not produce adverse effects in mice or pigs. The...

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Publicado no:Mol Ther
Main Authors: Gow, Deborah J, Sauter, Kristin A, Pridans, Clare, Moffat, Lindsey, Sehgal, Anuj, Stutchfield, Ben M, Raza, Sobia, Beard, Philippa M, Tsai, Yi Ting, Bainbridge, Graeme, Boner, Pamela L, Fici, Greg, Garcia-Tapia, David, Martin, Roger A, Oliphant, Theodore, Shelly, John A, Tiwari, Raksha, Wilson, Thomas L, Smith, Lee B, Mabbott, Neil A, Hume, David A
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4435485/
https://ncbi.nlm.nih.gov/pubmed/24962162
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2014.112
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