Interactions of the KWK(6) cationic peptide with short nucleic acid oligomers: demonstration of large Coulombic end effects on binding at 0.1–0.2 M salt

We quantify Coulombic end effects (CEE) on oligocation–nucleic acid interactions at salt concentrations ([salt]) in the physiological range. Binding constants (K(obs); per site, at zero binding density) for the +8-charged C-amidated oligopeptide KWK(6) and short single-stranded DNA oligonucleotides...

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Hlavní autoři: Ballin, Jeff D., Shkel, Irina A., Record, M. Thomas
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2004
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC443526/
https://ncbi.nlm.nih.gov/pubmed/15205469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkh646
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