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Liver-specific expression of the agouti gene in transgenic mice promotes liver carcinogenesis in the absence of obesity and diabetes

BACKGROUND: The agouti protein is a paracrine factor that is normally present in the skin of many species of mammals. Agouti regulates the switch between black and yellow hair pigmentation by signalling through the melanocortin 1 receptor (Mc1r) on melanocytes. Lethal yellow (A(y)) and viable yellow...

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Udgivet i:Mol Cancer
Principais autores: Kuklin, Alexander I, Mynatt, Randall L, Klebig, Mitchell L, Kiefer, Laura L, Wilkison, William O, Woychik, Richard P, Michaud, Edward J
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2004
Fag:
Research
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC443512/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15175105/
https://ncbi.nlm.nih.govhttps://doi.org/10.1186/1476-4598-3-17
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