A pharmacokinetic comparison of two voriconazole formulations and the effect of CYP2C19 polymorphism on their pharmacokinetic profiles

PURPOSE: SYP-1018 is a lyophilized polymeric nanoparticle formulation of voriconazole that is under development for intravenous dosing. This study compared the pharmacokinetic and tolerability profiles of SYP-1018 with those of Vfend(®), the marketed formulation of voriconazole. The effect of CYP2C1...

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Vydáno v:Drug Des Devel Ther
Hlavní autoři: Chung, Hyewon, Lee, Howard, Han, HyeKyung, An, Hyungmi, Lim, Kyoung Soo, Lee, Yong Jin, Cho, Joo-Youn, Yoon, Seo Hyun, Jang, In-Jin, Yu, Kyung-Sang
Médium: Artigo
Jazyk:Inglês
Vydáno: Dove Medical Press 2015
Témata:
Original Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4435089/
https://ncbi.nlm.nih.gov/pubmed/25999694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S80066
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